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apparent diffusion coefficient adc maps  (Bruker Corporation)


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    Structured Review

    Bruker Corporation apparent diffusion coefficient adc maps
    A. The percentage of viable and necrotic tissue with respect to the total lesion volume. B.The evolution of vessel radius (R). C. Blood volume fraction (BVF). D. Oxygen saturation (StO 2 ) E. Signal enhancement F. Apparent diffusion <t>coefficient</t> <t>(ADC)</t> observed by MRI at D4, D7, D14, D28, and D56 after ischemic injury by malonate injection. n=5 at D4, n=13 at D7, n=8 at D14, n=8 at D28 and n=7 at D56. Data is represented by medians and IQR. *: 0.03>p>0.01, **: 0.005>p>0.001, ***: 0.0005>p>0.0001, ****: p<0.0001 vs contralateral hemisphere, paired non-parametric Mann-Whitney test.
    Apparent Diffusion Coefficient Adc Maps, supplied by Bruker Corporation, used in various techniques. Bioz Stars score: 97/100, based on 3085 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
    https://www.bioz.com/product/apparent-diffusion-coefficient/Diffusion/bio_rxiv__2025__10__22__684053-75-0-10
    Average 97 stars, based on 3085 article reviews
    apparent diffusion coefficient adc maps - by Bioz Stars, 2026-11
    97/100 stars

    Images

    1) Product Images from "Multimodal Characterization and Evolution of Malonate-induced Stroke Model: Advanced MRI, Histology-Molecular Profiling"

    Article Title: Multimodal Characterization and Evolution of Malonate-induced Stroke Model: Advanced MRI, Histology-Molecular Profiling

    Journal: bioRxiv

    doi: 10.1101/2025.10.22.684053

    A. The percentage of viable and necrotic tissue with respect to the total lesion volume. B.The evolution of vessel radius (R). C. Blood volume fraction (BVF). D. Oxygen saturation (StO 2 ) E. Signal enhancement F. Apparent diffusion coefficient (ADC) observed by MRI at D4, D7, D14, D28, and D56 after ischemic injury by malonate injection. n=5 at D4, n=13 at D7, n=8 at D14, n=8 at D28 and n=7 at D56. Data is represented by medians and IQR. *: 0.03>p>0.01, **: 0.005>p>0.001, ***: 0.0005>p>0.0001, ****: p<0.0001 vs contralateral hemisphere, paired non-parametric Mann-Whitney test.
    Figure Legend Snippet: A. The percentage of viable and necrotic tissue with respect to the total lesion volume. B.The evolution of vessel radius (R). C. Blood volume fraction (BVF). D. Oxygen saturation (StO 2 ) E. Signal enhancement F. Apparent diffusion coefficient (ADC) observed by MRI at D4, D7, D14, D28, and D56 after ischemic injury by malonate injection. n=5 at D4, n=13 at D7, n=8 at D14, n=8 at D28 and n=7 at D56. Data is represented by medians and IQR. *: 0.03>p>0.01, **: 0.005>p>0.001, ***: 0.0005>p>0.0001, ****: p<0.0001 vs contralateral hemisphere, paired non-parametric Mann-Whitney test.

    Techniques Used: Diffusion-based Assay, Injection, MANN-WHITNEY

    Related Articles

    Diffusion-based Assay:

    Article Title: Multiparametric MRI to Predict Response to Irreversible Electroporation Plus Anti‐ PD ‐1 Immunotherapy in Pancreatic Ductal Adenocarcinoma
    Article Snippet: .. For DWI, the apparent diffusion coefficient (ADC) was analyzed using ParaVision 6.0.1 software (Bruker Biospin). ..

    Article Title: Amelioration of Tumor-promoting Microenvironment via Vascular Remodeling and CAF Suppression Using E7130: Biomarker Analysis by Multimodal Imaging Modalities
    Article Snippet: E7130 is a novel anticancer agent created from total synthetic study of the natural compound norhalichondrin B.. In addition to inhibiting microtubule dynamics, E7130 also ameliorates tumorpromoting aspects of the tumor microenvironment (TME) by suppressing cancer-associated fibroblasts (CAF) and promoting remodeling of tumor vasculature.. Here, we demonstrate TME amelioration by E7130 using multi-imaging modalities, including multiplexed mass cytometry [cytometry by time-of-flight (CyTOF)] analysis, multiplex IHC analysis, and MRI.

    Article Title: Depleting parenchymal border macrophages alleviates cerebral edema and neuroinflammation following status epilepticus.
    Article Snippet: .. Apparent diffusion coefficient (ADC) images were generated from DWI scans using Paravision v.6.0.1 software (Bruker), and regions of interest (ROIs) were traced for the cortex on brain slices (bregma 1.0 to −2.5 mm). ..

    Article Title: Multimodal Characterization and Evolution of Malonate-induced Stroke Model: Advanced MRI, Histology-Molecular Profiling
    Article Snippet: The MRI data were reconstructed and analyzed using MP3 software developed in MATLAB (MathWorks, USA). .. Apparent diffusion coefficient (ADC) maps were automatically computed on the Bruker scanner as the means of the ADCs observed in each of three orthogonal directions. ..

    Article Title: Intratumoral heterogeneity after targeted therapy in murine cancer models with differing degrees of malignancy.
    Article Snippet: .. The pixel-wise apparent diffusion coefficient (ADC) was calculated by the Bruker software. ..

    Article Title: Tauroursodeoxycholic acid reduces brain lesion volume and cortical edema in a rat model of Traumatic brain injury.
    Article Snippet: Background: Traumatic brain injury (TBI) continues to be a major cause of death and disability worldwide.. Effective treatment options are limited, and randomized clinical data has been futile.. Objective: In this study, we assessed the efficacy of tauroursodeoxycholic acid (TUDCA) in treating TBI using a controlled cortical impact injury model in male Wistar rats.

    Article Title: Neoadjuvant toripalimab combined with axitinib in patients with locally advanced clear cell renal cell carcinoma: a single-arm, phase II trial.
    Article Snippet: .. ADC: apparent diffusion coefficient. (C) Baseline biomarkers correlated with response to treatment analyzed by NanoString IO 360. ..

    Software:

    Article Title: Multiparametric MRI to Predict Response to Irreversible Electroporation Plus Anti‐ PD ‐1 Immunotherapy in Pancreatic Ductal Adenocarcinoma
    Article Snippet: .. For DWI, the apparent diffusion coefficient (ADC) was analyzed using ParaVision 6.0.1 software (Bruker Biospin). ..

    Article Title: Amelioration of Tumor-promoting Microenvironment via Vascular Remodeling and CAF Suppression Using E7130: Biomarker Analysis by Multimodal Imaging Modalities
    Article Snippet: E7130 is a novel anticancer agent created from total synthetic study of the natural compound norhalichondrin B.. In addition to inhibiting microtubule dynamics, E7130 also ameliorates tumorpromoting aspects of the tumor microenvironment (TME) by suppressing cancer-associated fibroblasts (CAF) and promoting remodeling of tumor vasculature.. Here, we demonstrate TME amelioration by E7130 using multi-imaging modalities, including multiplexed mass cytometry [cytometry by time-of-flight (CyTOF)] analysis, multiplex IHC analysis, and MRI.

    Article Title: Depleting parenchymal border macrophages alleviates cerebral edema and neuroinflammation following status epilepticus.
    Article Snippet: .. Apparent diffusion coefficient (ADC) images were generated from DWI scans using Paravision v.6.0.1 software (Bruker), and regions of interest (ROIs) were traced for the cortex on brain slices (bregma 1.0 to −2.5 mm). ..

    Article Title: Depleting parenchymal border macrophages alleviates cerebral edema and neuroinflammation following status epilepticus
    Article Snippet: .. Apparent diffusion coefficient (ADC) images were generated from DWI scans using Paravision v.6.0.1 software (Bruker), and regions of interest (ROIs) were traced for the cortex on brain slices (bregma 1.0 to −2.5 mm). ..

    Generated:

    Article Title: Amelioration of Tumor-promoting Microenvironment via Vascular Remodeling and CAF Suppression Using E7130: Biomarker Analysis by Multimodal Imaging Modalities
    Article Snippet: E7130 is a novel anticancer agent created from total synthetic study of the natural compound norhalichondrin B.. In addition to inhibiting microtubule dynamics, E7130 also ameliorates tumorpromoting aspects of the tumor microenvironment (TME) by suppressing cancer-associated fibroblasts (CAF) and promoting remodeling of tumor vasculature.. Here, we demonstrate TME amelioration by E7130 using multi-imaging modalities, including multiplexed mass cytometry [cytometry by time-of-flight (CyTOF)] analysis, multiplex IHC analysis, and MRI.

    Article Title: Depleting parenchymal border macrophages alleviates cerebral edema and neuroinflammation following status epilepticus.
    Article Snippet: .. Apparent diffusion coefficient (ADC) images were generated from DWI scans using Paravision v.6.0.1 software (Bruker), and regions of interest (ROIs) were traced for the cortex on brain slices (bregma 1.0 to −2.5 mm). ..

    Article Title: Depleting parenchymal border macrophages alleviates cerebral edema and neuroinflammation following status epilepticus
    Article Snippet: .. Apparent diffusion coefficient (ADC) images were generated from DWI scans using Paravision v.6.0.1 software (Bruker), and regions of interest (ROIs) were traced for the cortex on brain slices (bregma 1.0 to −2.5 mm). ..

    Article Title: Tauroursodeoxycholic acid reduces brain lesion volume and cortical edema in a rat model of Traumatic brain injury.
    Article Snippet: Background: Traumatic brain injury (TBI) continues to be a major cause of death and disability worldwide.. Effective treatment options are limited, and randomized clinical data has been futile.. Objective: In this study, we assessed the efficacy of tauroursodeoxycholic acid (TUDCA) in treating TBI using a controlled cortical impact injury model in male Wistar rats.

    Sequencing:

    Article Title: Amelioration of Tumor-promoting Microenvironment via Vascular Remodeling and CAF Suppression Using E7130: Biomarker Analysis by Multimodal Imaging Modalities
    Article Snippet: E7130 is a novel anticancer agent created from total synthetic study of the natural compound norhalichondrin B.. In addition to inhibiting microtubule dynamics, E7130 also ameliorates tumorpromoting aspects of the tumor microenvironment (TME) by suppressing cancer-associated fibroblasts (CAF) and promoting remodeling of tumor vasculature.. Here, we demonstrate TME amelioration by E7130 using multi-imaging modalities, including multiplexed mass cytometry [cytometry by time-of-flight (CyTOF)] analysis, multiplex IHC analysis, and MRI.



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    A. The percentage of viable and necrotic tissue with respect to the total lesion volume. B.The evolution of vessel radius (R). C. Blood volume fraction (BVF). D. Oxygen saturation (StO 2 ) E. Signal enhancement F. Apparent diffusion <t>coefficient</t> <t>(ADC)</t> observed by MRI at D4, D7, D14, D28, and D56 after ischemic injury by malonate injection. n=5 at D4, n=13 at D7, n=8 at D14, n=8 at D28 and n=7 at D56. Data is represented by medians and IQR. *: 0.03>p>0.01, **: 0.005>p>0.001, ***: 0.0005>p>0.0001, ****: p<0.0001 vs contralateral hemisphere, paired non-parametric Mann-Whitney test.
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    Figure 4 (A and B) MRI and pathological alterations in patients before and after axitinib plus toripalimab administration. (A) Example of highly immune infiltrated tumor; (B) example of minimally infiltrated tumor. ADC: apparent diffusion <t>coefficient.</t> (C) Baseline biomarkers correlated with response to treatment analyzed by NanoString IO 360. The volcano plot displays differential gene expression at baseline. (D). Relative fraction of tumor-infiltrating lymphocytes. Each row represents an immune cell subpopulation estimated by multiplexed immunofluorescence, including the density of PD1+ cells, PD1+CD8+ cells, PD- L1+ cells, PD-L1+CK+ cells, CD3+ cells, CD4+ cells, CD8+ cells, CD20+ cells, CD56+ cells, FOXP3+ cells, CD68+CD163- macrophage cells M1, CD68+CD163+ macrophage cells M2. The relative infiltrations of each lymphocyte subpopulations were normalized into a z-score. (E). Comparison of density levels of tumor-infiltrating PD1+ cells, PD1+CD8+ cells, PD-L1+ cells, PD- L1+CK+ cells between partial response (PR) and SD patients. *, p<0.05. (F). Comparison of density levels of tumor-infiltrating CD3+ cells, CD4+ cells, CD8+ cells, CD20+ cells, CD56+ cells, FOXP3+ cells, M1 macrophages, and M2 macrophages between PR and SD patients. No significant differences were found. (G). Representative multiplexed immunofluorescence images showing the simultaneous staining of panel 1 (left): DAPI (blue), CD8+ (red), PD-1+ (green), PD-L1+ (yellow), and CK (gray). Panel 2 (right): DAPI (blue), CD3+ (red), CD4+ (green), FOXP3+ (yellow), CD20+ (orange), and CK (gray) in PR (up) and SD (bottom) patients. Scale bar: 20 µm.
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    Image Search Results


    A. The percentage of viable and necrotic tissue with respect to the total lesion volume. B.The evolution of vessel radius (R). C. Blood volume fraction (BVF). D. Oxygen saturation (StO 2 ) E. Signal enhancement F. Apparent diffusion coefficient (ADC) observed by MRI at D4, D7, D14, D28, and D56 after ischemic injury by malonate injection. n=5 at D4, n=13 at D7, n=8 at D14, n=8 at D28 and n=7 at D56. Data is represented by medians and IQR. *: 0.03>p>0.01, **: 0.005>p>0.001, ***: 0.0005>p>0.0001, ****: p<0.0001 vs contralateral hemisphere, paired non-parametric Mann-Whitney test.

    Journal: bioRxiv

    Article Title: Multimodal Characterization and Evolution of Malonate-induced Stroke Model: Advanced MRI, Histology-Molecular Profiling

    doi: 10.1101/2025.10.22.684053

    Figure Lengend Snippet: A. The percentage of viable and necrotic tissue with respect to the total lesion volume. B.The evolution of vessel radius (R). C. Blood volume fraction (BVF). D. Oxygen saturation (StO 2 ) E. Signal enhancement F. Apparent diffusion coefficient (ADC) observed by MRI at D4, D7, D14, D28, and D56 after ischemic injury by malonate injection. n=5 at D4, n=13 at D7, n=8 at D14, n=8 at D28 and n=7 at D56. Data is represented by medians and IQR. *: 0.03>p>0.01, **: 0.005>p>0.001, ***: 0.0005>p>0.0001, ****: p<0.0001 vs contralateral hemisphere, paired non-parametric Mann-Whitney test.

    Article Snippet: Apparent diffusion coefficient (ADC) maps were automatically computed on the Bruker scanner as the means of the ADCs observed in each of three orthogonal directions.

    Techniques: Diffusion-based Assay, Injection, MANN-WHITNEY

    Figure 4 (A and B) MRI and pathological alterations in patients before and after axitinib plus toripalimab administration. (A) Example of highly immune infiltrated tumor; (B) example of minimally infiltrated tumor. ADC: apparent diffusion coefficient. (C) Baseline biomarkers correlated with response to treatment analyzed by NanoString IO 360. The volcano plot displays differential gene expression at baseline. (D). Relative fraction of tumor-infiltrating lymphocytes. Each row represents an immune cell subpopulation estimated by multiplexed immunofluorescence, including the density of PD1+ cells, PD1+CD8+ cells, PD- L1+ cells, PD-L1+CK+ cells, CD3+ cells, CD4+ cells, CD8+ cells, CD20+ cells, CD56+ cells, FOXP3+ cells, CD68+CD163- macrophage cells M1, CD68+CD163+ macrophage cells M2. The relative infiltrations of each lymphocyte subpopulations were normalized into a z-score. (E). Comparison of density levels of tumor-infiltrating PD1+ cells, PD1+CD8+ cells, PD-L1+ cells, PD- L1+CK+ cells between partial response (PR) and SD patients. *, p<0.05. (F). Comparison of density levels of tumor-infiltrating CD3+ cells, CD4+ cells, CD8+ cells, CD20+ cells, CD56+ cells, FOXP3+ cells, M1 macrophages, and M2 macrophages between PR and SD patients. No significant differences were found. (G). Representative multiplexed immunofluorescence images showing the simultaneous staining of panel 1 (left): DAPI (blue), CD8+ (red), PD-1+ (green), PD-L1+ (yellow), and CK (gray). Panel 2 (right): DAPI (blue), CD3+ (red), CD4+ (green), FOXP3+ (yellow), CD20+ (orange), and CK (gray) in PR (up) and SD (bottom) patients. Scale bar: 20 µm.

    Journal: Journal for immunotherapy of cancer

    Article Title: Neoadjuvant toripalimab combined with axitinib in patients with locally advanced clear cell renal cell carcinoma: a single-arm, phase II trial.

    doi: 10.1136/jitc-2023-008475

    Figure Lengend Snippet: Figure 4 (A and B) MRI and pathological alterations in patients before and after axitinib plus toripalimab administration. (A) Example of highly immune infiltrated tumor; (B) example of minimally infiltrated tumor. ADC: apparent diffusion coefficient. (C) Baseline biomarkers correlated with response to treatment analyzed by NanoString IO 360. The volcano plot displays differential gene expression at baseline. (D). Relative fraction of tumor-infiltrating lymphocytes. Each row represents an immune cell subpopulation estimated by multiplexed immunofluorescence, including the density of PD1+ cells, PD1+CD8+ cells, PD- L1+ cells, PD-L1+CK+ cells, CD3+ cells, CD4+ cells, CD8+ cells, CD20+ cells, CD56+ cells, FOXP3+ cells, CD68+CD163- macrophage cells M1, CD68+CD163+ macrophage cells M2. The relative infiltrations of each lymphocyte subpopulations were normalized into a z-score. (E). Comparison of density levels of tumor-infiltrating PD1+ cells, PD1+CD8+ cells, PD-L1+ cells, PD- L1+CK+ cells between partial response (PR) and SD patients. *, p<0.05. (F). Comparison of density levels of tumor-infiltrating CD3+ cells, CD4+ cells, CD8+ cells, CD20+ cells, CD56+ cells, FOXP3+ cells, M1 macrophages, and M2 macrophages between PR and SD patients. No significant differences were found. (G). Representative multiplexed immunofluorescence images showing the simultaneous staining of panel 1 (left): DAPI (blue), CD8+ (red), PD-1+ (green), PD-L1+ (yellow), and CK (gray). Panel 2 (right): DAPI (blue), CD3+ (red), CD4+ (green), FOXP3+ (yellow), CD20+ (orange), and CK (gray) in PR (up) and SD (bottom) patients. Scale bar: 20 µm.

    Article Snippet: ADC: apparent diffusion coefficient. (C) Baseline biomarkers correlated with response to treatment analyzed by NanoString IO 360.

    Techniques: Diffusion-based Assay, Gene Expression, Immunofluorescence, Comparison, Staining